Evid Based Med doi:10.1136/eb-2012-101128
  • Therapeutics
  • Systematic review with meta-analysis

Network meta-analysis shows that prostaglandin inhibitors and nifedipine are best short-term tocolytics for preterm delivery

  1. Sheri Jenkins
  1. Department of Obstetrics & Gynecology, University of Alabama, Birmingham, Alabama, USA
  1. Correspondence to : Dr Adi Abramovici
    Department of Obstetrics & Gynecology, University of Alabama at Birmingham, 10270C Women and Infants Center, 1700 6th Avenue South, Birmingham, AL 35249, USA;  aabramovici{at}

Commentary on:


Preterm birth is the leading cause of perinatal morbidity and mortality and a major source of healthcare costs. Despite advances in obstetrical care, the incidence of preterm birth is at an all-time high and may be rising due to increasing rates of advancing maternal age, maternal medical conditions, assisted reproductive technology and multiple gestations.1 Prevention of preterm birth and its associated neonatal morbidity and mortality are major concerns and a significant focus for obstetrical research. Tocolytics have not been shown to decrease the risk for preterm birth, but they have been associated with a short-term delay in delivery. Therefore, the primary goal of tocolysis is to allow administration of glucocorticoids in order to reduce the risk …

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