Context

Several computer-based decision models have demonstrated the effectiveness and cost-effectiveness of colorectal cancer (CRC) screening with any of the recommended tests and strategies.1 These strategies include annual high-sensitivity guaiac-based faecal occult blood testing or faecal immunochemical testing, CT colonography every 5 years and colonoscopy every 10 years.2 For each strategy, the models simulate CRC-related outcomes such as CRC incidence and mortality, life-years, complications and costs, and assume that persons use the same screening test repeatedly. The models further assume a certain starting age (usually, age 50) for screening the population, which is screened for a certain time interval (usually 25–30 years) and then followed until death. On a continuum with the …