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Systematic review and meta-analysis
Use of cranberry products does not appear to be associated with a significant reduction in incidence of recurrent urinary tract infections
  1. Armando J Lorenzo1,
  2. Luis H P Braga2
  1. 1Division of Pediatric Urology, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada
  2. 2Department of Urology, McMaster University, Toronto, Ontario, Canada
  1. Correspondence to : Armando J Lorenzo
    Department of Pediatric Urology, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada; armando.lorenzo{at}sickkids.ca

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Context

Urinary tract infections (UTIs) represent a considerable healthcare burden, with important consequences in terms of morbidity and cost. Preventive measures are limited, not always dramatically effective1 and associated with a concerning increase in the resistance profile of common pathogens to different antibiotics. Thus, there is considerable interest in alternative prophylactic interventions. Among these, cranberry products (CP) are often recommended and utilised. The study by Jepson and colleagues updates a previous analysis on the use of CP for this purpose.

Methods

The authors conducted a systematic review and meta-analysis (SR/MA) of pertinent literature identified by a comprehensive search strategy with an in-depth assessment of randomised and quasi-randomised trials of CP (vs placebo and non-placebo controls) in preventing UTIs. Two investigators independently evaluated and extracted information on methods, participants, interventions …

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