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Randomised controlled trial
Long-term supplementation with multivitamins and minerals did not improve male US physicians’ cardiovascular health or prolong their lives
  1. Marta Ebbing,
  2. Stein E Vollset
  1. Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway
  1. Correspondence to: Dr Marta Ebbing
    Division of Epidemiology, Norwegian Institute of Public Health, Kalfarveien 31, Bergen 5018, Norway; marta.ebbing{at}

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Commentary on: Sesso HD, Christen WG, Bubes V, et al. Multivitamins in the prevention of cardiovascular disease in men: the Physicians’ Health Study II randomized controlled trial. JAMA 2012;308:1751–60.


Cardiovascular disease (CVD) is the leading cause of death and disability worldwide. Behavioural risk factors, including tobacco use, physical inactivity, unhealthy diet and the harmful use of alcohol, are estimated to be responsible for about 80% of coronary heart disease and cerebrovascular disease.1 Until 2000, observational studies found inverse associations between vitamin intake and CVD outcomes. Thus, randomised controlled clinical trials (RCTs) were needed to test the effect of vitamin supplementation in primary or secondary prevention of CVD.2 The Physicians’ Health Study II (PHSII) RCT is the largest to date, evaluating the effects of long-term use of …

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