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Randomised controlled trial
A Mediterranean diet supplemented with olive oil or nuts reduces the incidence of major cardiovascular events in high-risk patients
  1. Demosthenes Panagiotakos
  1. Department of Nutrition and Dietetics, Harokopio University, Athens, Greece
  1. Correspondence to: Professor Demosthenes Panagiotakos
    Department of Nutrition and Dietetics, Harokopio University, 70 Eleftheriou Venizelou, Athens 17671, Greece; dbpanag{at}hua.gr

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Context

The Mediterranean diet has long been associated with lower risk for cardiovascular disease (CVD) events, which is mainly based on results from observational studies.

Methods

The PREDIMED study was a well-designed, large-scale randomised trial of 7447 middle-aged participants from Spain with high cardiovascular risk but no CVD. The participants were allocated to three groups: a Mediterranean diet supplemented with extravirgin olive oil (group 1), a Mediterranean diet supplemented with nuts (group 2) and a control group that followed a healthy diet with strong advice to reduce dietary fat (group 3). The primary endpoint of the …

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