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Gastro-oesophageal reflux disease (GORD) is common in western countries. Up to 40% experience symptoms at least once a month and 10% of adults use proton pump inhibitor (PPI) medication for GORD.1 The REFLUX study addresses a question fundamental to the management of this problem: what is the best treatment strategy? The current study reports 5-year outcomes of a multicentre randomised clinical trial of surgery versus medical management in the UK.
This randomised controlled trial (RCT) included individuals with objective evidence of GORD who had undergone PPI treatment with reasonable control of GORD symptoms for at least 12 months whom the …