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Ibuprofen does not seem to increase global malformation risk but NSAID use in late pregnancy remains a concern
  1. Christine Damase-Michel,
  2. Caroline Hurault-Delarue
  1. Service de Pharmacologie, Faculté de Médecine, Centre Hospitalier Universitaire, INSERM UMR1027, Université de Toulouse III, 31000 Toulouse, France
  1. Correspondence to: Dr Christine Damase-Michel, Service de Pharmacologie, Faculté de médecine, Centre Hospitalier Universitaire, INSERM UMR1027, Université de Toulouse III, 31000 Toulouse, France; christine.damase-michel{at}univ-tlse3.fr

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Context

Non-steroidal anti-inflammatory drugs (NSAIDs) are a first-line therapy for frequent medical conditions. The known risks of NSAIDs used in late pregnancy (risk of premature closure of the ductus arteriosus (DA), decreased fetal and neonatal renal function) have led to their contraindication. These effects are linked to their pharmacological properties. Several studies considering NSAIDs as a group have suggested an increased risk of miscarriage or cardiac defects when these drugs are used in early pregnancy.

Nezvalová-Henriksen and colleagues have investigated the individual effects of four frequently used NSAIDs on pregnancy outcome, focusing on effects potentially related to the pharmacological properties of NSAIDs such as bleeding and asthma.

Methods

Between 1999 and 2006, data from the Norwegian mother …

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