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Beyond genetics: focusing on maternal environment for congenital heart disease prevention
  1. Vidu Garg,
  2. Madhumita Basu
  1. Center for Cardiovascular and Pulmonary Research, Nationwide Children's Hospital, Columbus, Ohio, USA
  1. Correspondence to: Dr Vidu Garg, Center for Cardiovascular and Pulmonary Research, Nationwide Children's Hospital, 700 Children's Drive, Room WB4221, Columbus, OH 43205, USA; vidu.garg{at}nationwidechildrens.org

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Congenital heart disease (CHD) is the most common birth defect, accounting for about one-quarter of birth defects resulting in mortality.1 Aetiology for the majority of CHD remains unknown, but is thought to be multifactorial with genetic and environmental (non-genetic) contributors. Advances in molecular biology and genetic technologies have aided identification of genetic contributors for CHD. Increasing numbers of genomic abnormalities have been discovered in individuals with CHD using next-generation sequencing and array-based methodologies.2 While great strides have been made, genetic aetiologies are identified in only a subset of CHD.2

Epidemiological studies have demonstrated …

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