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Systematic review and meta-analysis
Blood pressure reduction in elderly patients with hypertension decreases risk of adverse cardiovascular outcomes
  1. Sripal Bangalore1,
  2. Bethany Doran2
  1. 1Division of Cardiology, New York School of Medicine, New York, New York, USA
  2. 2New York School of Medicine, New York, New York, USA
  1. Correspondence to: Dr Sripal Bangalore, Division of Cardiology, New York University School of Medicine, New York, NY 10016, USA; sripalbangalore{at}gmail.com

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Context

In individuals over 65-years old, uncontrolled hypertension has been associated with increased risk of stroke, as well as all-cause and cardiovascular death.1–3 However, optimal blood pressure (BP) targets in the elderly remain uncertain.4 Briasoulis and colleagues examine the effect of antihypertensive treatment on outcomes in individuals over the age of 65.

Methods

This systematic review of 18 randomised trials enrolled patients aged over 65 with hypertension. Trials were divided into two subgroups: group 1 compared antihypertensive treatment to placebo, while group 2 compared two antihypertensive treatment groups. Outcomes included all-cause mortality, cardiovascular mortality, stroke and heart failure. A …

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