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Systematic review and meta-analysis
Combined oral contraceptives increase risk of venous thrombosis according to oestrogen dose and type of progestogen
  1. Per Morten Sandset
  1. Department of Haematology and Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet and University of Oslo, Oslo, Norway
  1. Correspondence to: Professor Per Morten Sandset, Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Box 4950 Nydalen, N-0424 Oslo, Norway; p.m.sandset{at}medisin.uio.no

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There is compelling evidence that use of combined oral contraceptives (COCs) is associated with a two-to-fourfold increased risk of venous thrombosis (ie, either deep venous thrombosis or pulmonary embolism).1 Although the risks have been assessed for various combinations of oestrogen dose and type of progestogen in COCs, the findings of these assessments have been debated and a comprehensive comparison of the commonly used COCs has …

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