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The glycaemic portion of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial showed that an intensive glucose-lowering strategy may increase overall and cardiovascular (CV) mortality, as compared with a standard management.1 However, it is unclear whether age may influence the effects of intensive glycaemic control. Answering this question is of particular relevance since: (1) diabetes prevalence in individuals over 65 years is increasing; (2) the characteristics of diabetes in the elderly may differ from those in younger patients and (3) limited information is available in the elderly population since it is poorly represented in most diabetes trials.
This is a retrospective subgroup analysis on the ACCORD trial dataset, assessing …
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