Article Text

other Versions

PDF
Randomised controlled trial
Until questions on intraprocedural efficacy control, renal nerve distribution and predictors of BP response are answered, the interpretation of clinical trials on renal denervation will remain uncertain
  1. Luca Donazzan,
  2. Sebastian Ewen,
  3. Michael Böhm
  1. Klinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, Homburg, Germany
  1. Correspondence to: Professor Michael Böhm, Klinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, Kirrberger Str. 1, Geb. 40, Homburg/Saar D-66421, Germany; michael.boehm{at}uks.eu

Statistics from Altmetric.com

Commentary on: OpenUrlCrossRefPubMedWeb of Science

Context

Percutaneous renal artery denervation (RDN) has recently been developed as an invasive technique to reduce blood pressure (BP) in patients with resistant hypertension. It is based on the principle of interrupting sympathetic renal afferent and efferent nerves, thereby reducing sympathetic activity. Several studies and registries documented a significant reduction in office and ambulatory BP after RDN and a persisting BP response during long-term follow-up.1 ,2 However, the recently published Symplicity HTN-3 study failed to meet its primary efficacy end point, while the primary safety end point was met.

Methods

HTN-3 was a prospective, 2:1 randomised, single-blinded trial comparing the safety and efficacy of RDN to an invasive sham procedure (renal artery angiography with sedation) using the Symplicity Flex System. Only 535 of 1441 initially evaluated patients could satisfy the inclusion criteria of office systolic BP (SBP) ≥160 mm Hg and ambulatory SBP ≥135 mm Hg after …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.