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Cohort study
Study results suggest a positive effect of light-to-moderate physical activity on disability among those with or at risk of knee arthritis
  1. Maura D Iversen
  1. Department of Physical Therapy, Movement and Rehabilitation Sciences, Northeastern University; Brigham & Women's Hospital, Boston, Massachusetts, USA
  1. Correspondence to: Professor Maura D Iversen, Department of Physical Therapy, Movement and Rehabilitation Sciences, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, USA; m.iversen{at}

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Knee osteoarthritis (KOA) is a leading cause of disability worldwide and its prevalence increases with age.1 Annual costs due to disability in the USA reached nearly $357 billion in 2010.2 Data indicate that engagement in regular physical activity leads to improved physical function, endurance and mood state, and has the potential to reduce disability.3 This prospective cohort study examines the risk of incident disability and progression of disability in community-dwelling adults with or at risk for KOA.


This multisite study included 1680 community-dwelling adults aged 49 and older, either affected by or with established risk factors for KOA, to examine onset of disability. To determine progression of disability, a second cohort of …

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