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Systematic review with meta analysis
Potential confounding still clouds the possible association of maternal caffeine intake and low birth weight
  1. Michael B Bracken
  1. Yale University, Schools of Public Health and Medicine, Yale Center for Perinatal, Pediatric and Environmental Epidemiology, New Haven, Connecticut, USA
  1. Correspondence to: Dr Michael B Bracken, Yale University, Schools of Public Health and Medicine, Yale Center for Perinatal, Pediatric and Environmental Epidemiology, 1 Church Street, 6th Floor, New Haven, CT 06510, USA; michael.bracken{at}yale.edu

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Context

The possible association of maternal caffeine intake to a variety of pregnancy outcomes (eg, low birth weight (LBW), fetal growth restriction, preterm delivery) is important because of widespread exposure to caffeine. If caffeine were causally related to these outcomes, it would be amenable to risk reduction through caffeine reduction or abstention.

Methods

This was a systematic review and meta-analysis of prospective observational studies of maternal caffeine exposure and LBW. The Meta-analysis Of Observational Studies in Epidemiology (MOOSE) guidelines were followed. Acceptable standards for literature searching, study selection and data extraction were adhered …

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