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Randomised controlled trial
Supplemental oxygen in patients without hypoxia in ST segment elevation myocardial infarction increases myocardial injury and infarct size
  1. Gabriele Crimi
  1. SC Cardiologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
  1. Correspondence to : Dr Gabriele Crimi, SC Cardiologia, Fondazione IRCCS Policlinico San Matteo, Piazzale Golgi 1, Pavia 27100, Italy; gabrielecrimi{at}gmail.com

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Context

In patients with ST segment elevation myocardial infarction (STEMI), timely reperfusion, best obtained with primary percutaneous coronary intervention (pPCI), is a mainstay to reduce infarct size (IS) and improve clinical outcome. Routine oxygen administration in normoxic patients with STEMI before pPCI, while mentioned by international guidelines,1 is not supported by randomised evidence. Stub and colleagues performed the AVOID study to compare oxygen supplementation (8 L/min) versus no supplementation in patients with STEMI undergoing primary PCI.

Methods

The authors conducted a multicentre prospective randomised controlled trial in Melbourne, Australia. Patients were screened and randomised by paramedics: any patient with chest pain <12 h and ECG evidence of STEMI was eligible. Patients …

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