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Randomised controlled trial
In hypertensive patients with elevated risk of cardiovascular disease, targeting systolic blood pressure to less than 120 mm Hg significantly reduces the rate of fatal and non-fatal cardiovascular events as well as death from any cause
  1. Mina Owlia,
  2. Sripal Bangalore
  1. Department of Cardiology, University School of Medicine, New York, New York, USA
  1. Correspondence to : Dr Sripal Bangalore, Department of Cardiology, New York University School of Medicine, New York, NY 10016, USA; sripalbangalore{at}gmail.com

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Context

Hypertension is among the most significant modifiable risk factor for cardiovascular disease, yet there is considerable debate on the optimal blood pressure (BP) goal. Observational studies1 and the ACCORD trial2 suggest a target organ heterogeneity in that with lower systolic BP goals (<120 mm Hg) the risk of cerebrovascular events are reduced, but not coronary events. As such, systolic BP goals of <130, <140 or <150 mm Hg, have been proposed in the last decade by hypertension guideline societies.3 ,4

Methods

SPRINT was a randomised, controlled, open-label trial of targeted BP treatment to the standard BP goal (<140 mm Hg) …

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