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  • Caffeine does not increase the arrhythmic burden in patients with heart failure and left ventricular systolic dysfunction

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Commentary
General medicine
Caffeine does not increase the arrhythmic burden in patients with heart failure and left ventricular systolic dysfunction
  1. Daniel Caldeira
  1. Laboratório de Farmacologia Clínica e Terapêutica, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal
  1. Correspondence to Professor Daniel Caldeira, Laboratório de Farmacologia Clínica e Terapêutica, Faculdade de Medicina, Universidade de Lisboa. Av. Prof. Egas Moniz, Lisboa, 1649-028, Portugal; dgcaldeira{at}hotmail.com

https://doi.org/10.1136/ebmed-2017-110729

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    Commentary on: Zuchinali P, Souza GC, Pimentel M, et al. Short-term effects of high-dose caffeine on cardiac arrhythmias in patients with heart failure: a randomized clinical trial. JAMA Intern Med 2016;176:1752–1759.

    Context

    Caffeine is a major component of some of the most widely consumed beverages, such as coffee. The role of caffeine in arrhythmias has always been controversial and the impact of caffeine on patients at high risk of arrhythmias it is not established.

    Methods

    This was a single-centre double-blinded randomised controlled trial (RCT) comparing the effect of caffeinated coffee (capsules with 100 mg of caffeine given hourly with decaffeinated coffee until 500 mg) and decaffeinated coffee (placebo lactose capsules) in patients with chronic heart failure (HF), New York Heart Association (NYHA) classes between I and III and left ventricular (LV) …

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    Footnotes

    • Competing interests None declared.

    • Provenance and peer review Commissioned; internally peer reviewed.