TY - JOUR T1 - Alendronate increased bone mineral density and decreased vertebral fractures in men with osteoporosis JF - Evidence Based Medicine JO - Evid Based Med SP - 55 LP - 55 DO - 10.1136/ebm.6.2.55 VL - 6 IS - 2 A2 - , Y1 - 2001/03/01 UR - http://ebm.bmj.com/content/6/2/55.abstract N2 - (2000) N Engl J Med 343, 604. Orwoll E, Ettinger M, Weiss S, et al.. Alendronate for the treatment of osteoporosis in men.. Aug 31;. :. –10.OpenUrlCrossRefPubMedWeb of Science
 
 QUESTIONS: In men with osteoporosis, does alendronate prevent or reverse bone loss, and does it decrease vertebral fractures? Randomised {allocation concealed*}†, blinded (patients and outcome assessors),* controlled trial with 2 year follow up. 20 centres in the US and 10 in other countries. 241 men (mean age 63 y) who met either of the following sets of criteria: bone mineral density (BMD) at the femoral neck ≥2 SDs below the mean value in normal young men and a BMD at the lumbar spine ≥1 SD below the mean value in normal young men; or femoral neck BMD ≥1 SD below the mean in normal young men and ≥1 vertebral deformity or a history of an osteoporotic fracture. Exclusion criteria included secondary causes … ER -