TY - JOUR T1 - Fifty years of age-based screening: time for a new risk-based screening approach JF - Evidence Based Medicine JO - Evid Based Med SP - 183 LP - 183 DO - 10.1136/eb-2014-101798 VL - 19 IS - 5 AU - Karla Kerlikowske AU - Margaret E O'Kane AU - Laura J Esserman Y1 - 2014/10/01 UR - http://ebm.bmj.com/content/19/5/183.abstract N2 - Commentary on: Miller AB, Wall C, Baines CJ, et al. Twenty five year follow-up for breast cancer incidence and mortality of the Canadian National Breast Screening Study: randomised screening trial. BMJ 2014;348:g366.OpenUrlAbstract/FREE Full Text The first screening mammography trial was conducted over 50 years ago; however, even today there is an ongoing debate over whether screening mammography averts breast cancer deaths. In the USA, the estimated cost of mammography screening in 2010 was $7.8 billion, endorsing strong acceptance that women should undergo screening mammography.1 The Canadian National Breast Screening Study (CNBS) results provide evidence to challenge whether routine, widespread annual screening mammography is indicated in large numbers of women. CNBS-1 randomised women aged 40–49 years to undergo either annual mammography and clinical breast examination (CBE) or usual care. The CNBS-2 … ER -