TY - JOUR T1 - Oxycodone administered as postpartum pain relief is associated with maternal report of infant central nervous system depression in breastfed infants JF - Evidence Based Medicine JO - Evid Based Med DO - 10.1136/ebmed-2012-100777 SP - ebmed-2012-100777 AU - Wibke Christina Jonas Y1 - 2012/06/01 UR - http://ebm.bmj.com/content/early/2012/06/25/ebmed-2012-100777.abstract N2 - Commentary on: Lam J, Kelly L, Ciszkowski C, et al. Central nervous system depression of neonates breastfed by mothers receiving oxycodone for postpartum analgesia. J Pediatr 2012;160:33–7.e2.OpenUrlCrossRefPubMedWeb of Science Despite our knowledge that codeine is excreted in breast milk, administration of codeine as a pain relief to breastfeeding mothers during the early postpartum period was considered safe until a healthy newborn died.1 The mother was an ultra-rapid metaboliser of codeine and thus, produced effectively the metabolite morphine. As a consequence, the guidelines for codeine use during breastfeeding were changed to include more caution about the possible central nervous system (CNS) depression effects on the neonate.2 As a result, many clinicians started to prescribe oxycodone, a semisynthetic opioid, instead. Little is known about the excretion of oxycodone into breast milk and the safety for newborns to mothers taking oxycodone while breastfeeding. Lam et al … ER -