TY - JOUR T1 - Among statin-treated patients, LDL, non-HDL and apoB cholesterol biomarkers were associated with increased risks of cardiovascular events JF - Evidence Based Medicine JO - Evid Based Med DO - 10.1136/eb-2012-100787 SP - ebmed-2012-100787 AU - Allan David Sniderman AU - George Thanassoulis Y1 - 2012/08/01 UR - http://ebm.bmj.com/content/early/2012/08/13/eb-2012-100787.abstract N2 - Commentary on: Boekholdt SM, Arsenault BJ, Mora S, et al. Association of LDL cholesterol, non-HDL cholesterol, and apolipoprotein B levels with risk of cardiovascular events among patients treated with statins: a meta-analysis. JAMA 2012;307:1302–9.OpenUrlCrossRefPubMedWeb of Science Each very-low-density lipoprotein and low-density lipoprotein (LDL) particle contains one molecule of apolipoprotein B (apoB). Increased numbers of cholesterol-depleted LDL particles are common in patients with hypertriglyceridaemia, premature vascular disease, obesity and type-2 diabetes mellitus and much in vitro and in vivo evidence indicates cholesterol-depleted LDL particles are at least as atherogenic as larger, more cholesterol-replete LDL particles.1 Nevertheless, … ER -