TY - JOUR T1 - Low-dose levothyroxine did not improve symptoms in asymptomatic older people with subclinical hypothyroidism JF - BMJ Evidence-Based Medicine JO - BMJ EBM SP - 39 LP - 40 DO - 10.1136/ebmed-2017-110819 VL - 23 IS - 1 AU - Simon H S Pearce AU - Earn H Gan Y1 - 2018/02/01 UR - http://ebm.bmj.com/content/23/1/39.abstract N2 - Commentary on: Stott DJ, Rodondi N, Kearney PM, et al. Thyroid hormone therapy for older adults with subclinical hypothyroidism. N Engl J Med 2017;376:2534–44.Subclinical hypothyroidism (SCH), defined as an elevated serum thyroid-stimulating hormone (TSH) with normal circulating free thyroid hormones, is a common and frequently asymptomatic condition. SCH becomes increasingly prevalent with advancing age,1 and current guidelines recommend no treatment for older patients with serum TSH concentrations between the upper limit of the reference range and 10 mU/L.2 However, as numerous large epidemiological studies show an excess of cardiovascular events and/or increased mortality in patients with SCH,3 there are important questions about whether long-term levothyroxine treatment could either ameliorate vascular risk in this population or improve symptoms of hypothyroidism.In this study,4 737 individuals over the age of 65 years were recruited by … ER -