Angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) v calcium antagonists (CAs) or placebo for diabetes with and without nephropathy*
| Outcomes | Comparisons | Number of trials (n) | Relative risk (95% CI) |
|---|---|---|---|
| *CI defined in glossary. | |||
| †Not significant. | |||
| Onset of microalbuminuria in diabetes without nephropathy | ACE inhibitors v CAs | 4 (1210) | 0.58 (0.40 to 0.84) |
| ACE inhibitors v placebo | 6 (3840) | 0.60 (0.43 to 0.84) | |
| All cause mortality in diabetic nephropathy | ACE inhibitors v placebo | 20 (2838) | 0.79 (0.63 to 0.99) |
| ARBs v placebo | 4 (3329) | 0.99 (0.85 to 1.17)† | |