Effectiveness and adverse effects of various doses of antidepressant drugs*
| Imipramine equivalent doses | Average percentage of patients showing improvement (95% CI) | Average adverse events per week (CI) |
|---|---|---|
| *Statistically different from placebo. | ||
| Placebo | 35% (25 to 44) | 0.22 (0.13 to 0.33) |
| <100 mg/day | 46% (37 to 55) | 0.22 (0.13 to 0.33) |
| 100 to 200 mg/day | 53% (48 to 59)* | 0.30 (0.21 to 0.39) |
| 201 to 250 mg/day | 46% (35 to 58) | 0.36 (0.23 to 0.52) |
| >250 mg/day | 48% (37 to 60) | 0.48 (0.32 to 0.67) |