Patients continuing initial and any antidepressant medication: fluoxetine (Flu) v desipramine (Des) and imipramine (Imi)‡
| Outcomes at 12 mo | Comparison | Continuation rates | RBI (95% CI) | NNT (CI) |
|---|---|---|---|---|
| Continuing initial medication | Flu v Des | 42% v 20% | 107% (43 to 201) | 5 (4 to 10) |
| Flu v Imi | 42% v 27% | 56% (13 to 117) | 7 (4 to 25) |
| RBR (CI) | NNH | |||
|---|---|---|---|---|
| ‡RBR = relative benefit reduction. Other abbreviations defined in glossary; RBI, RBR, NNT, NNH, and CI calculated from data supplied by author. | ||||
| Continuing any medication | Flu v Des | 51% v 54% | 6.8% (−16 to 25) | Not significant |
| Flu v Imi | 51% v 50% | 1.4% (−28 to 19) | Not significant | |