NRT-assisted reduction-to-stop smoking v placebo in smokers unable or unwilling to quit abruptly*
| Outcomes | Number of trials (n) | Weighted event rates | RBI (95% CI) | NNT (CI) |
| Smoking abstinence for 6 months | 5 (1833) | 6.8% v 3.3% | 106% (34 to 215) | 29 (15 to 90) |
| Smoking abstinence, week 6 to study end | 7 (2767) | 1.2% v 0.4% | 244% (48 to 696) | 114 (40 to 579) |
| Sustained smoking reduction, week 6 to study end | 6 (2233) | 6.1% v 1.6% | 284% (132 to 535) | 23 (12 to 48) |
| RRI (CI) | NNH (CI) | |||
| Nausea | 6 (2233) | 8.6% v 5.3% | 63% (20 to 120) | 30 (16 to 96) |
| Serious adverse events | 6 (2233) | 7.7% v 7.1% | 8% (−20 to 45) | NS |
*NRT, nicotine replacement therapy; NS, not significant; other abbreviations defined in glossary. Weighted event rates, RBI, RRI, NNT, NNH, and CI calculated from data in article using a fixed-effect model.
*NRT, nicotine replacement therapy; NS, not significant; other abbreviations defined in glossary. Weighted event rates, RBI, RRI, NNT, NNH, and CI calculated from data in article using a fixed-effect model.