Thrombolysis v placebo or open control for acute ischaemic stroke*
| Weighted event rates | |||||
|---|---|---|---|---|---|
| Outcomes | Number of trials | Thrombolysis | Control | RRI (95% CI) | NNH (CI) |
| Death at 7 to 10 d | 7 | 16.6% | 9.8% | 69% (39 to 106) | 15 (11 to 25) |
| SIH or FIH at 7 to 10 d | 17 | 9.4% | 2.5% | 273% (186 to 388) | 15 (13 to 18) |
| Death at 1 to 6 mo† | 17 | 19.0% | 15.9% | 19% (–3 to 45) | NS |
| RRR (CI) | NNT (CI) | ||||
|---|---|---|---|---|---|
| *FIH = fatal intracranial haemorrhage; NS = not significant; SIH = symptomatic intracranial haemorrhage. Other abbreviations defined in glossary; RRI, RRR, NNH, NNT, and CI calculated from data in article. | |||||
| †Random effects model used because heterogeneity existed. | |||||
| Death or dependence at 1 to 6 months | 12 | 55% | 70% | 7% (3 to 12) | 23 (14 to 67) |