Antidepressants v placebo for chronic headache*

Weighted event rates†
Outcome at 4 to 27 weeksAntidepressantsPlaceboRBI (95% CI)NNT (CI)
*Meta-analyses were done using a random effects model. Abbreviations defined in glossary; RBI, NNT, and CI calculated from data in article.
†Information provided by author.
Overall improvement65%33%100% (60 to 140)4 (3 to 5)