Different dosing frequencies of 10 day penicillin or amoxicillin for acute group A β-haemolytic streptococcal tonsillopharyngitis†
| Comparisons | Number of RCTs | Weighted cure rates | RBR (95% CI) | NNH (CI) |
|---|---|---|---|---|
| †RBR = relative benefit reduction; RCTs = randomised controlled trials. Other abbreviations defined in glossary; RBR, NNH, and CI calculated from data in article. | ||||
| ‡Heterogeneity is statistically significant. | ||||
| §Study involving amoxicillin was excluded. | ||||
| Twice/day v 3 or 4 times/day | 4 | 84% v 85% | 2% (−5 to 8) | Not significant |
| Once/day v 3 or 4 times/day | 3‡ | 85% v 92% | 8% (−7 to 20) | Not significant |
| Once/day v 3 or 4 times/day (excluding the amoxicillin study) | 2§ | 79% v 91% | 14% (4 to 23) | 9 (5 to 31) |