Oral anticoagulants (OAs) v control treatment in patients with established coronary artery disease*
| Outcomes | OA intensity and comparison | OAs | Control | Odds reduction (95% CI) | NNT (CI) |
|---|---|---|---|---|---|
| High v control | 20.3% | 30.1% | 43% (37 to 49) | 10 (9 to 12) | |
| Moderate v control | 31.3% | 33.7% | 16% (−34 to 20) | Not significant | |
| Death, MI, or stroke | High or moderate v aspirin | 11.3% | 12.6% | 4% (−34 to 20) | Not significant |
| Odds increase (CI) | NNH (CI) | ||||
|---|---|---|---|---|---|
| *Abbreviations defined in glossary; NNTs and NNHs calculated from data in article. Follow up data not available. | |||||
| †Approximate value calculated assuming a control event rate of 0.1%. | |||||
| High v control | 4.6% | 0.7% | 600% (440 to 820) | 30 (21 to 44) | |
| Moderate v control | 3.5% | 0% | 770% (330 to 1760) | 151 (42 to 437)† | |
| Major bleeding | High or moderate v aspirin | 3.7% | 1.0% | 1.4% (0.6 to 2.6) | 74 (40 to 170) |