Coumadin or coumadin plus aspirin (combination group) v aspirin alone in acute myocardial infarction or unstable angina at median follow up of 12 months†
| Outcomes | Comparisons | Event rates | RRR (95% CI) | NNT (CI) |
|---|---|---|---|---|
| Composite end point | Coumadin v aspirin | 5% v 9% | 43% (1 to 68) | 26 (13 to 2740) |
| Combination v aspirin | 5% v 9% | 48% (7 to 71) | 23 (12 to 184) |
| RRI (CI) | NNH (CI) | |||
|---|---|---|---|---|
| †Composite end point = all cause mortality, myocardial infarction, or stroke. Abbreviations defined in glossary; RRI, RRR, NNT, NNH, and CI calculated from data in article. | ||||
| Major bleeding | Coumadin v aspirin | 1% v 1% | 3% (−76 to 345) | Not significant |
| Combination v aspirin | 2% v 1% | 136% (−32 to 733) | Not significant | |
| Minor bleeding | Coumadin v aspirin | 8% v 5% | 68% (−7 to 205) | Not significant |
| Combination v aspirin | 15% v 5% | 216% (86 to 442) | 10 (7 to 17) | |