Alendronate v placebo in postmenopausal women with osteoporosis and ≥1 existing vertebral fracture‡
| Cumulative incidence rate | ||||
|---|---|---|---|---|
| Outcomes at 3 years | Alendronate | Placebo | RRR (95% CI) | NNT (CI) |
| ‡Abbreviations defined in glossary; RRR, NNT, and CI were estimated from a proportional hazards model. | ||||
| ≥1 day of bed rest | 11% | 15% | 32% (13 to 47) | 23 (15 to 56) |
| ≥7 days of bed rest | 4% | 9% | 56% (36 to 70) | 21 (17 to 32) |
| ≥7 days of limited activity | 41% | 44% | 13% (1 to 24) | 23 (12 to 308) |