Any antibiotic v placebo in preterm, prelabour rupture of membranes*

Weighted event rates
OutcomesAny antibiotic v placeboRRR (95% CI)NNT (CI)
Maternal infection after delivery and before discharge18% v 20%15% (4 to 24)33 (19 to 143)
Chorioamnionitis16% v 26%38% (25 to 49)11 (8 to 17)
Birth within 24 hours32% v 40%23% (17 to 28)12 (9 to 16)
Birth within 7 days8% v 67%12% (8 to 16)13 (10 to 19)
Neonatal infection, including pneumonia11% v 17%33% (15 to 48)18 (12 to 46)
Positive neonatal blood culture6.4% v 8.4%25% (7 to 40)48 (27 to 200)
Neonatal oxygenation > 28 days8.5% v 11%19% (3 to 32)48 (27 to 334)
Abnormal cerebral ultrasonographic scan before discharge5.6% v 9.4%18% (1 to 32)67 (35 to 1000)
Macrolide antibiotics v placebo
Birth within 48 hours35% v 41%16% (7 to 24)16 (10 to 35)
β-Lactam antibiotics v placeboRRI (CI)NNH (CI)
*Abbreviations defined in glossary; RRR, RRI, NNT, NNH, and CI calculated from data in article using fixed effects.
Neonatal necrotising enterocolitis2.4% v 0.48%360% (98 to 972)53 (36 to 112)