Ophthalmic non-steroidal anti-inflammatory drugs (NSAIDs) v placebo or standard therapy in acute corneal abrasions at 1–24 hours*

Outcome	Comparisons (1 RCT each)	n	Scale	Difference between groups (95% CI or p value)†
*RCT = randomised controlled trial; VAS = visual analogue scale; NPIS = Numeric Pain Intensity Scale scores; NR = magnitude of effect not reported. CI defined in glossary. †All significant differences favour NSAIDs. ‡0 = no pain and 10 = severe pain. §Difference ≥13 mm on a 100 mm visual analogue scale (clinically important difference).
	Ketorolac 0.5% v “control vehicle”	100	0–10‡	1.3 (p=0.002)§
	Diclofenac 0.1% v normal saline	40	0–100 mm VAS	NR (p<0.05)
	Indomethacin 0.1% plus gentamycin sulphate v gentamycin sulphate	123	0–100 mm VAS	5.9 (p=0.007)
	Ketorolac 0.5% v liquifilm tears	85	0–50 mm VAS	2 (p<0.05)
Mean reduction in pain intensity from baseline	Diclofenac 0.1% v natural tears	49	0–100 mm NPIS	21 (8 to 34)§