Diagnostic properties of the conventional cervical smear (CCS) test, monolayer cytology (MLC), and human papillomavirus (HPV) testing for detecting cervical intraepithelial neoplasia*
| Test | Women referred for colposcopy | Women presenting for routine smears | ||||||
|---|---|---|---|---|---|---|---|---|
| Sensitivity (95% CI) | Specificity (CI) | +LR | −LR | Sensitivity (CI) | Specificity (CI) | +LR | −LR | |
| *Abnormality threshold = atypical squamous cells or glandular cells of undetermined significance for CCS test and MLC, and relative light units >1 for HPV testing. Diagnostic terms defined in glossary. †Clinical reading. | ||||||||
| CCS test† | 95% (93 to 97) | 60% (55 to 66) | 2.4 | 0.1 | 72% (63 to 80) | 94% (93 to 95) | 11.5 | 0.3 |
| MLC† | 92% (90 to 95) | 58% (52 to 64) | 2.2 | 0.1 | 66% (56 to 75) | 91% (90 to 93) | 7.5 | 0.4 |
| HPV testing | 82% (77 to 86) | 74% (67 to 80) | 3.1 | 0.3 | 69% (58 to 79) | 83% (81 to 85) | 4.1 | 0.4 |