Antidepressants for increasing smoking cessation rates at ⩾6 months*
| Comparisons | Number of RCTs | Weighted event rates | RBI (95% CI) | NNT (CI) |
|---|---|---|---|---|
| *NRT = nicotine replacement therapy; RBR = relative benefit reduction; RCTs = randomised controlled trials; SSRIs = selective serotonin reuptake inhibitors. Other abbreviations defined in glossary; weighted event rates, RBI, NNT, RBR, NNH, and CI calculated from data in article. | ||||
| †In 1 RCT, both groups also received nicotine replacement therapy. | ||||
| Nortriptyline v placebo | 5† | 19% v 7.6% | 144% (66 to 257) | 10 (7 to 15) |
| Moclobemide v placebo | 1 | 25% v 16% | 57% (−31 to 263) | Not significant |
| Bupropion v placebo | 16 | 18% v 10% | 75% (52 to 102) | 13 (10 to 17) |
| Bupropion v NRT | 1 | 18% v 9.8% | 88% (19 to 197) | 12 (7 to 41) |
| Venlafaxine v placebo | 1 | 25% v 20% | 25% (−33 to 134) | Not significant |
| Bupropion v nortriptyline | 1 | 16% v 9.6% | 71% (−26 to 303) | Not significant |
| RBR (CI) | NNH | |||
| Bupropion v NRT | 1 | 19% v 24% | 20% (−29 to 51) | Not significant |
| SSRIs v placebo | 4 | 15% v 15% | 3% (−26 to 25) | Not significant |