Rhesus, bovine, and human rotavirus vaccines v placebo in children at ⩽4 years*
| Outcomes | Number of RCTs (n) | Comparisons | Weighted event rates | RRR (95% CI) | NNT (CI) |
|---|---|---|---|---|---|
| *RCTs = randomised controlled trials. Abbreviations defined in glossary; RRR, RRI, NNT, NNH, CI, and weighted event rates calculated from data in article using a random effects model. | |||||
| Rotavirus diarrhoea | 20 (13 305) | Rhesus v placebo | 11% v 19% | 41% (30 to 50) | 13 (12 to 17) |
| 17 (5283) | Bovine v placebo | 11% v 18% | 41% (24 to 55) | 15 (10 to 25) | |
| 3 (2482) | Human v placebo | 3% v 12% | 58% (15 to 79) | 12 (6 to ∞) | |
| All cause diarrhoea | 11 (7706) | Rhesus v placebo | 54% v 63% | 14% (8 to 20) | 12 (9 to 20) |
| 11 (3309) | Bovine v placebo | 28% v 37% | 27% (11 to 40) | 10 (6 to 25) | |
| 1 (281) | Human v placebo | 19% v 21% | 9% (−44 to 43) | Not significant | |
| All cause mortality | 4 (6029) | Rhesus v placebo | 0.16% v 0.18% | 28% (−212 to 84) | Not significant |
| RRI (CI) | NNH (CI) | ||||
| Fever | 32 (13 718) | Rhesus v placebo | 35% v 23% | 100% (51 to 164) | 9 (7 to 15) |