Test characteristics of D-dimer assays for diagnosis of deep venous thrombosis (DVT) and pulmonary embolism (PE)*
| D-dimer test | Sensitivity (95% CI) | Specificity (CI) | +LR | −LR |
|---|---|---|---|---|
| *Based on data from 69 studies of DVT and 42 studies of PE. Diagnostic terms defined in glossary. | ||||
| Diagnosis of DVT | ||||
| ELISA | 95% (91 to 99) | 40% (32 to 49) | 1.60 | 0.12 |
| Quantitative rapid ELISA | 96% (90 to 100) | 44% (34 to 54) | 1.71 | 0.10 |
| Semiquantitative rapid ELISA | 90% (83 to 98) | 39% (29 to 50) | 1.48 | 0.25 |
| Qualitative rapid ELISA | 93% (87 to 99) | 46% (35 to 57) | 1.73 | 0.15 |
| Quantitative latex | 86% (78 to 94) | 61% (51 to 71) | 2.20 | 0.23 |
| Semiquantitative latex | 79% (69 to 88) | 66% (57 to 75) | 2.33 | 0.32 |
| Whole blood | 86% (80 to 93) | 67% (61 to 73) | 2.62 | 0.20 |
| Diagnosis of PE | ||||
| ELISA | 96% (88 to 100) | 51% (44 to 59) | 1.97 | 0.08 |
| Quantitative rapid ELISA | 97% (87 to 100) | 41% (30 to 51) | 1.64 | 0.07 |
| Semiquantitative rapid ELISA | 93% (79 to 100) | 40% (27 to 54) | 1.55 | 0.18 |
| Qualitative rapid ELISA | 91% (68 to 100) | 70% (47 to 93) | 3.01 | 0.13 |
| Quantitative latex | 89% (80 to 99) | 47% (38 to 57) | 1.69 | 0.23 |
| Semiquantitative latex | 80% (65 to 94) | 56% (42 to 70) | 1.81 | 0.36 |
| Whole blood | 83% (74 to 92) | 64% (55 to 73) | 2.32 | 0.27 |