Reporting of assignment methods in clinical trials
References (6)
- et al.
Randomized controlled study of orchidectomy vs. long-acting D-Trp-6LHRH microcapsules in advanced prostatic carcinoma
The Lancet
(1985) - et al.
Fundamentals of Clinical Trials
(1985) Controlled clinical trials in the 1980's: A bibliography
Controlled Clinical Trials
(1991)
Cited by (26)
Randomized clinical trials (CONSORT)
2005, Medicina ClinicaQuantification methods were developed for selection bias by predictability of allocations with unequal block randomization
2005, Journal of Clinical EpidemiologyCitation Excerpt :In multicenter trials, contracts with individual investigator sites usually stipulate a fixed number of subjects to be enrolled (commonly 8 to 20), so that the study can be planned and managed properly. If the ratio of treatment arms is known (e.g., equal allocations to two treatment arms), and if the trial is not double-blind [1], or if the treatments do not resemble each other perfectly as to appearance [2] or effects, the eligibility and consent of patients may be biased by anticipating the next treatment allocation before the patients are enrolled [3–8]. For example, Peto [9] discussed the results of the Captopril Prevention project [10]: because some allocation envelopes had been opened in advance in an unknown proportion of cases, the outcome could be “distorted by foreknowledge of the next treatment allocation.”
When can a clinical trial be called 'randomized'?
2003, VaccineCitation Excerpt :With the consumer principle of randomization [9], patients may actually choose their own randomization probability from a given set of choices. So randomization can be quite broad, allowing for uneven allocation [8], adaptive probabilities [10], and even some degree of self-selection [9]. Yet not every allocation method is randomized.
Chapter 1 Randomized Controlled Trials: Methodology, Outcomes, and Interpretation
2001, Blue Books of Practical NeurologyMinimization in randomized clinical trials
2023, Statistics in Medicine