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BMJ Journals

Drugs: respiratory system

Inhaled corticosteroids for people with chronic obstructive pulmonary disease are associated with an increased risk of fracture
Nirupama Putcha, M Bradley Drummond

BMJ Evidence-Based Medicine Jun 2012, 17 (3) 90-91; DOI: 10.1136/ebm.2011.100221
Tiotropium is superior to salmeterol in reducing frequency of exacerbations: but the effect of adding tiotropium to the combination of inhaled corticosteroid and long-acting β(2)-agonist remains unclear
Rick Hodder

BMJ Evidence-Based Medicine Jun 2012, 17 (3) 93-95; DOI: 10.1136/ebmed.2011.100206
In two parallel pragmatic equivalence trials, leukotriene receptor antagonists as initial therapy for asthma compared with inhaled corticosteroids and as add on therapy to ICS compared with adding long-acting β agonists provided equivalent short-term asthma quality of life but were associated with more medication switches
J Mark FitzGerald

BMJ Evidence-Based Medicine Apr 2012, 17 (2) 44-45; DOI: 10.1136/ebm.2011.100140
Epinephrine for acute bronchiolitis, but not steroids alone, reduces hospital admissions
Shawn Ralston

BMJ Evidence-Based Medicine Feb 2012, 17 (1) 12-13; DOI: 10.1136/ebm.2011.100055
Similar rates of relapse and time to return to normal activity with 2 or 5 days of systemic corticosteroids after asthma exacerbation but study confirmation of equivalence would require further study
Brian H Rowe

BMJ Evidence-Based Medicine Feb 2012, 17 (1) 23-24; DOI: 10.1136/ebmed.2011.100257
In children and adolescents with mild persistent asthma, daily beclomethasone reduces treatment failure compared with rescue beclomethasone plus albuterol
Tom Kovesi

BMJ Evidence-Based Medicine Dec 2011, 16 (6) 183-184; DOI: 10.1136/ebm1411
Tiotropium mist inhaler for COPD increases risk of mortality compared with placebo
Felix S F Ram

BMJ Evidence-Based Medicine Dec 2011, 16 (6) 189-190; DOI: 10.1136/ebm.2011.100171
In preterm infants with recurrent apnoea, methylxanthine reduces the number of episodes and the use of mechanical ventilation in the short term; caffeine is also associated with improved longer term outcomes
Luigi Corvaglia, Arianna Aceti

BMJ Evidence-Based Medicine Aug 2011, 16 (4) 120-121; DOI: 10.1136/ebm1207
Allergen-specific immunotherapy improves asthma symptoms compared with placebo, but the possibility of adverse effects should be considered
Rabia Rashid, Anthony J Frew

BMJ Evidence-Based Medicine Feb 2011, 16 (1) 16-17; DOI: 10.1136/ebm1144
Long-acting β-agonist step-up therapy is more likely to provide best response, compared to inhaled corticosteroid or leukotriene-receptor antagonist step-up in children with uncontrolled asthma receiving inhaled corticosteroids
Mike Thomas

BMJ Evidence-Based Medicine Dec 2010, 15 (6) 167-168; DOI: 10.1136/ebm1117

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