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Q In patients with actinic keratoses (AK), is a topically applied imiquimod 5% cream more effective than placebo for clearing lesions?
Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Dermatology ★★★★★★☆
2 concurrent randomised controlled trials subsequently merged into 1 trial for data analysis purposes.
blinded (patients, healthcare providers, data collectors, outcome assessors, data analysts, and the sponsor).*
Follow up period:
16 weeks of treatment followed by an 8 week observational period.
24 centres in the US and Canada.
436 otherwise healthy people >18 years of age (mean age 66 y, 87% men) who had 4–8 clinically diagnosed AK lesions within a contiguous 25 cm2 treatment area on the face …