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Topically applied imiquimod 5% cream cleared actinic keratosis lesions

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 Q In patients with actinic keratoses (AK), is a topically applied imiquimod 5% cream more effective than placebo for clearing lesions?

Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Dermatology ★★★★★★☆


Embedded ImageDesign:

2 concurrent randomised controlled trials subsequently merged into 1 trial for data analysis purposes.

Embedded ImageAllocation:


Embedded ImageBlinding:

blinded (patients, healthcare providers, data collectors, outcome assessors, data analysts, and the sponsor).*

Embedded ImageFollow up period:

16 weeks of treatment followed by an 8 week observational period.

Embedded ImageSetting:

24 centres in the US and Canada.

Embedded ImagePatients:

436 otherwise healthy people >18 years of age (mean age 66 y, 87% men) who had 4–8 clinically diagnosed AK lesions within a contiguous 25 cm2 treatment area on the face …

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  • * See glossary.

  • For correspondence: Dr M Lebwohl, Mount Sinai School of Medicine, New York, NY, USA. Lebwohl{at}

  • Source of funding: not stated.