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Therapeutics
Ginger was equivalent to pyridoxine hydrochloride (vitamin B6) for reducing nausea and vomiting in pregnancy

https://doi.org/10.1136/ebm.10.1.14

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    Smith C, Crowther C, Willson K, et al. A randomized controlled trial of ginger to treat nausea and vomiting in pregnancy. Obstet Gynecol 2004;103:639–45.
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 Q In pregnant women who experience nausea and vomiting, is ginger equivalent to pyridoxine hydrochloride (vitamin B6) for controlling symptoms?

    Clinical impact ratings FP/GP/Obstetrics ★★★★★★☆ Obstetrics ★★★★★☆☆

    METHODS

    Embedded ImageDesign:

    randomised controlled equivalence trial.

    Embedded ImageAllocation:

    concealed.*

    Embedded ImageBlinding:

    blinded (patients, healthcare providers, and data collectors).*

    Embedded ImageFollow up period:

    3 weeks.

    Embedded ImageSetting:

    a hospital in Adelaide, South Australia, Australia.

    Embedded ImagePatients:

    291 women who were 8–16 weeks pregnant (confirmed by ultrasonography). Exclusion criteria: signs of clinical dehydration, allergy to ginger or pyridoxine, or suspicion that symptoms were not related to pregnancy.

    Embedded ImageIntervention:

    women were allocated to ginger, 350 mg capsule 3 times daily (n = 146), or pyridoxine, 25 mg capsule 3 times daily (n = 145), for 3 weeks.

    Embedded ImageOutcomes:

    nausea, dry retching, and vomiting (Rhodes Index of Nausea and Vomiting …

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    Footnotes

    • ↵* See glossary.

    • For correspondence: Dr C Smith, The University of Adelaide, Adelaide, South Australia, Australia. caroline.smith{at}unisa.edu.au

    • Source of Funding: Women’s and Children’s Hospital Research Foundation. Products supplied by Faulding Healthcare.