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Ginger was equivalent to pyridoxine hydrochloride (vitamin B6) for reducing nausea and vomiting in pregnancy

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 Q In pregnant women who experience nausea and vomiting, is ginger equivalent to pyridoxine hydrochloride (vitamin B6) for controlling symptoms?

Clinical impact ratings FP/GP/Obstetrics ★★★★★★☆ Obstetrics ★★★★★☆☆


Embedded ImageDesign:

randomised controlled equivalence trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

blinded (patients, healthcare providers, and data collectors).*

Embedded ImageFollow up period:

3 weeks.

Embedded ImageSetting:

a hospital in Adelaide, South Australia, Australia.

Embedded ImagePatients:

291 women who were 8–16 weeks pregnant (confirmed by ultrasonography). Exclusion criteria: signs of clinical dehydration, allergy to ginger or pyridoxine, or suspicion that symptoms were not related to pregnancy.

Embedded ImageIntervention:

women were allocated to ginger, 350 mg capsule 3 times daily (n = 146), or pyridoxine, 25 mg capsule 3 times daily (n = 145), for 3 weeks.

Embedded ImageOutcomes:

nausea, dry retching, and vomiting (Rhodes Index of Nausea and Vomiting …

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  • * See glossary.

  • For correspondence: Dr C Smith, The University of Adelaide, Adelaide, South Australia, Australia. caroline.smith{at}

  • Source of Funding: Women’s and Children’s Hospital Research Foundation. Products supplied by Faulding Healthcare.