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Q In patients with migraine, are anticonvulsants more effective than placebo for preventing or reducing the intensity of migraine attacks?
Clinical impact ratings GP/FP/Primary care ★★★★★☆☆IM/Ambulatory care ★★★★★★☆ Neurology ★★★★★☆☆
Medline (up to April 2003); the Cochrane Central Register of Controlled Trials (up to April 2003); review article references; books on headache; contact with drug companies, authors, and experts; and hand searches of Headache and Cephalalgia.
Study selection and assessment:
randomised controlled trials (RCTs) that compared anticonvulsants given regularly during headache free intervals in adults >18 years of age with placebo, no intervention, other drug treatments, or behavioural or physical therapies. Methodological quality was assessed using the Jadad 5 point scale.
headache frequency (number of migraine attacks measured at 28 d), headache index measures (frequency and intensity or duration), and adverse events.
15 RCTs met the selection criteria. Anticonvulsants investigated …
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