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Review: anticonvulsants are better than placebo for reducing the frequency of migraine attacks

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 Q In patients with migraine, are anticonvulsants more effective than placebo for preventing or reducing the intensity of migraine attacks?

Clinical impact ratings GP/FP/Primary care ★★★★★☆☆IM/Ambulatory care ★★★★★★☆ Neurology ★★★★★☆☆


Embedded ImageData sources:

Medline (up to April 2003); the Cochrane Central Register of Controlled Trials (up to April 2003); review article references; books on headache; contact with drug companies, authors, and experts; and hand searches of Headache and Cephalalgia.

Embedded ImageStudy selection and assessment:

randomised controlled trials (RCTs) that compared anticonvulsants given regularly during headache free intervals in adults >18 years of age with placebo, no intervention, other drug treatments, or behavioural or physical therapies. Methodological quality was assessed using the Jadad 5 point scale.

Embedded ImageOutcomes:

headache frequency (number of migraine attacks measured at 28 d), headache index measures (frequency and intensity or duration), and adverse events.


15 RCTs met the selection criteria. Anticonvulsants investigated …

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