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Review: intra-articular corticosteroid injections are better than placebo for improving symptoms of knee osteoarthritis

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 Q In patients with osteoarthritis (OA) of the knee, are intra-articular corticosteroid injections more effective than placebo for improving symptoms?

Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ IM/Ambulatory care ★★★★★☆☆ Rheumatology ★★★★★☆☆


Embedded ImageData sources:

Medline (1966–2003), EMBASE/Excerpta Medica (1980–2003), the Cochrane controlled trials register, hand searches, references of retrieved articles, and contact with authors.

Embedded ImageStudy selection and assessment:

randomised placebo controlled trials (RCTs) that assessed the efficacy of intra-articular corticosteroids of any duration for OA of the knee compared with placebo. Studies were assessed for methodological quality using the Jadad 5 point scale.

Embedded ImageOutcomes:

distinct improvement, subjective improvement, decreased pain, overall improvement, clinically relevant outcomes, and response to the OA research scale.


10 studies met the selection criteria (n = 546). The …

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