Article Text

Download PDFPDF
Loop diuretics and angiotensin converting enzyme inhibitors increased risk of hospital admission for lithium toxicity

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

 Q In older persons, is use of diuretics, angiotensin converting enzyme (ACE) inhibitors, or non-steroidal anti-inflammatory drugs (NSAIDs) associated with hospital admission for lithium toxicity?

Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ IM/Ambulatory care ★★★★☆☆☆ Emergency Medicine ★★★★★☆☆ Neurology ★★★★★☆☆ Geriatrics ★★★★★☆☆


Embedded ImageDesign:

population based, nested, case control study with analysis of multiple linked healthcare databases over 10 years.

Embedded ImageSetting:

Ontario, Canada.

Embedded ImagePatients:

10 615 patients ⩾66 years of age (mean age 72 y, 62% women) who were receiving uninterrupted lithium treatment and resided in Ontario, Canada.

Embedded ImageAssessment of risk factors:

use of diuretic (alone or in combination with another agent), ACE inhibitor, or prescription NSAID (including cyclooxygenase 2 inhibitors). Thiazide type and loop diuretics were examined separately.

Embedded ImageOutcome:

hospital admission with diagnosis of lithium toxicity within 28 days …

View Full Text


  • For correspondence: Dr D N Juurlink, University of Toronto, Toronto, Ontario, Canada. david.juurlink{at}

  • Sources of funding: Canadian Institutes of Health Research and Ontario Ministry of Health.