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Review: thrombolytic treatment does not reduce the risk of recurrent pulmonary embolism and death more than heparin
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 Q In patients with acute pulmonary embolism (PE), is initial treatment with thrombolysis more effective than heparin for reducing risk of recurrent PE and death?

Clinical impact ratings IM/Ambulatory care ★★★★★☆☆ Internal medicine ★★★★★☆☆ Emergency Medicine★★★★★☆☆ Respirology ★★★★★☆☆ Critical Care ★★★★★☆☆ Haematology ★★★★★☆☆ Cardiology ★★★★★☆☆

METHODS

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Medline and EMBASE/Excerpta Medica (January 1980 to January 2003), Cochrane Library (2003, Issue 1), and hand searches of reference lists of retrieved articles and abstracts of conference proceedings.

Embedded ImageStudy selection and assessment:

published and unpublished randomised controlled trials (RCTs) that were properly randomised, compared thrombolysis with heparin for initial treatment of patients with objectively diagnosed symptomatic PE, and used objective methods to assess clinical outcomes. 2 independent reviewers assessed methodological quality (allocation sequence and concealment, blinding, and …

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