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Atorvastatin reduced major cardiovascular disease events in type 2 diabetes mellitus
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 Q In patients with type 2 diabetes mellitus, is atorvastatin better than placebo for primary prevention of major cardiovascular disease (CVD) events?

Clinical impact ratings GP/FP/Primary care ★★★★★★☆ IM/Ambulatory care ★★★★★★☆ Endocrine ★★★★★★☆ Cardiology ★★★★★★☆

METHODS

Embedded ImageDesign:

randomised placebo controlled trial (Collaborative Atorvastatin Diabetes Study [CARDS]).

Embedded ImageAllocation:

concealed.*

Embedded ImageBlinding:

blinded (clinicians, patients, pharmacists, data collectors, outcome assessors, monitoring committee, and data analysts).*

Embedded ImageFollow-up period:

median 3.9 years.

Embedded ImageSetting:

132 clinical centres in the UK and Ireland.

Embedded ImagePatients:

2838 patients 40–75 years of age (mean age 62 y, 68% men) with type 2 diabetes mellitus (met 1985 World Health Organization criteria) who had ⩾1 of the following: a history of hypertension, retinopathy, microalbuminuria or macroalbuminuria, or a current smoking habit. Exclusion …

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