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Review: antidepressants increase clinical response and remission in bipolar depression without increasing induction of mania

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 Q What is the efficacy and safety of antidepressants for short term treatment of bipolar depression?

Clinical impact ratings Psychiatry ★★★★★★☆ GP/FP/Mental health ★★★★★★★


Embedded ImageData sources:

Cochrane Collaboration Depression, Anxiety, and Neurosis Controlled Trials register (December 2002), Cochrane Library, reference lists of identified studies, other relevant papers, and major textbooks.

Embedded ImageStudy selection and assessment:

randomised, controlled, double blind trials published in any language that compared antidepressants with placebo or alternative drugs (ie, mood stabilisers, anticonvulsants, or other antidepressants) in patients with a current depressive or mixed depressive/manic episode with or without psychotic symptoms who had had ⩾1 previous episode of mania or hypomania. Quality of studies was assessed.

Embedded ImageOutcomes:

clinical response and remission rates (observer rated symptom …

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  • For correspondence: Dr H Gijsman, Warneford Hospital, Oxford, UK.

  • Source of funding: no external funding.

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