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Q What is the efficacy and safety of antidepressants for short term treatment of bipolar depression?
Clinical impact ratings Psychiatry ★★★★★★☆ GP/FP/Mental health ★★★★★★★
Cochrane Collaboration Depression, Anxiety, and Neurosis Controlled Trials register (December 2002), Cochrane Library, reference lists of identified studies, other relevant papers, and major textbooks.
Study selection and assessment:
randomised, controlled, double blind trials published in any language that compared antidepressants with placebo or alternative drugs (ie, mood stabilisers, anticonvulsants, or other antidepressants) in patients with a current depressive or mixed depressive/manic episode with or without psychotic symptoms who had had ⩾1 previous episode of mania or hypomania. Quality of studies was assessed.
clinical response and remission rates (observer rated symptom …
For correspondence: Dr H Gijsman, Warneford Hospital, Oxford, UK.
Source of funding: no external funding.