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The following articles are abstracted in the March/April 2005 issue of ACP Journal Club. The declarative title of each abstract as published in ACP Journal Club precedes the article citation.


▹ Review: Low-dose but not high-dose corticosteroids reduced all-cause mortality in severe sepsis and septic shock

▹ Review: Glucocorticoids reduced mortality in sepsis in recent trials (post-1997), but not in previous (pre-1989), or all trials combined

▹ Review: Nonsteroidal antiinflammatory drugs provide better pain relief than do opioids for acute renal colic

▹ Review: Cardiac resynchronization therapy reduces mortality and hospitalization for heart failure

▹ Review: Oral and intravenous antibiotics do not differ for effectiveness in febrile neutropenic patients with cancer

▹ Lumiracoxib reduced ulcer complications compared with ibuprofen and naproxen in osteoarthritis and did not increase cardiovascular outcomes

▹ Routine invasive strategy within 24 hours of thrombolysis reduced death, nonfatal reinfarction, and ischemia-induced revascularization in STEMI

▹ A 10-day regimen of levofloxacin was not needed in patients with cellulitis who had an acceptable 5-day response

▹ Gly/Gly and Arg/Arg genotype responses to albuterol differed in mild asthma

▹ Dalteparin reduced venous thromboembolic events without increased bleeding in acutely ill medical patients

▹ Peginterferon α-2a alone or combined with lamivudine increased response rates more than lamivudine alone

▹ An early invasive strategy improved long-term freedom from major adverse cardiac events in older patients with angina

▹ Caspofungin was noninferior to amphotericin B for invasive fungal infections in persistent fever and neutropenia and better tolerated

▹ Stenting was not inferior to endarterectomy in patients with severe carotid-artery stenosis and coexisting conditions


▹ Reduced glomerular filtration rate was associated with increased death, cardiovascular events, and hospitalization

▹ Renal impairment increased mortality and cardiovascular complications after myocardial infarction