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Therapeutics
Review: statins reduce stroke but not stroke mortality

https://doi.org/10.1136/ebm.10.3.73

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    Amarenco P, Labreuche J, Lavallee P, et al. Statins in stroke prevention and carotid atherosclerosis: systematic review and up-to-date meta-analysis. Stroke 2004;35:2902–9.
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 Q Do 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) reduce fatal and non-fatal stroke more than placebo or usual care?

    Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Internal Medicine ★★★★★☆☆ Endocrine ★★★★★★☆ Neurology ★★★★★★☆

    METHODS

    Embedded ImageData sources:

    Medline and reference lists of identified trials.

    Embedded ImageStudy selection and assessment:

    randomised controlled trials (RCTs) and previous meta-analyses published before August 2003 that compared statins with placebo or usual care, included stroke events (brain infarction and haemorrhage) as outcomes, and used intention to treat analysis.

    Embedded ImageOutcomes:

    all stroke, fatal stroke, haemorrhagic stroke, the relation between stroke and low density lipoprotein cholesterol (LDL-C) reduction, and the relation between LDL-C reduction and change in carotid artery intima media thickness (IMT).

    MAIN RESULTS

    26 RCTs (n = 94 128) …

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    Footnotes

    • For correspondence: Professor P Amarenco, Bichat University Hospital, Paris, France. amarencoccr.jussieu.fr

    • Sources of funding: PHRC; SOS-ATTAQUE CEREBRALE Association; Formation de Recherche en Neurologie Vasculaire (Association Claude Bernard).